Ecosystem Health and Microbiomes
Ecosystems are essential to our survival and welfare, yet their health has been drastically impaired by extensive human activities. As a crucial component of ecosystems, microbes are at risk from environmental disturbances, but they also have the potential to mitigate these adverse effects. In the LEAPH Lab, we aim to leverage the power of the microbiome (i.e., all the microbes in a given environment) to generate innovative, sustainable solutions to protect and nurture natural and agricultural ecosystems. We employ field sampling, multi-omics, and machine learning to understand how environmental stresses caused by human activities interact with microbiomes. We further translate this knowledge into practical solutions to enhance ecosystem health and protect the environment by developing microbiome-based tools.
Food Safety and Bacterial Pathogens
Foodborne pathogens pose a heavy burden on public health and the food industry globally. However, it remains challenging to efficiently control them in the agricultural and food systems. We tackle this challenge by integrating environmental surveillance, whole genome sequencing, microbial ecology, and population genomics approaches. We monitor foodborne pathogens (chiefly Listeria monocytogenes, Salmonella, and pathogenic Escherichia coli) in diverse environments and identify genetic and environmental factors contributing to their distribution, adaptation, and transmission. We also develop ecological-informed tools for foodborne diseases control and outbreak investigation.
Antimicrobial Resistance in the Environment
Antimicrobial resistance (AMR) poses a serious and growing threat to human health globally. While the environment is an important reservoir of AMR, it is an overlooked dimension, which needs more investigations. To this end, we study AMR in two types of biological systems, microbiomes and foodborne pathogens, in food-associated and natural environments. Through (meta)genomic data analysis combined with experimental manipulation, we aim to understand ecological mechanisms underlying the persistence, dissemination, and evolution of AMR in the environment. We use the mechanistic knowledge to inform science-based decisions and environmental actions, ultimately mitigating the threats from AMR to public health.